The production of pellets composed of an ephedrine derivative

Details The production of pellets composed of an ephedrine derivative The production of pellets composed of an ephedrine derivative

A - Human Necessities

61

K

A61K 31/135 (2006.01) A61K 9/16 (2006.01) A61K 9/56 (2006.01) B01J 2/00 (2006.01)

Patent

CA 2105002

A process for producing pellets which are markedly spherical and have a particle size in the range from 0.1 to 4 mm and an apparent density above 0.5 g/cm3, and which are composed of 90-100% by weight of an ephedrine derivative and 0-10% by weight of a pharmaceutical aid, entails suspending ephedrine derivative powder with an average particle size of from 0.5 to 50 µm at 0-90°C with stirring in a water- immiscible non solvent with a boiling point in the range from 60 to 160°C, adding 5-60% by weight, based on the ephedrine derivative, of an agglomerating liquid while continuing stirring, and, if there has been previous heating, cooling to from -5 to 25°C at 5-40 K per. hour, with the stirring speed being adjusted after the agglome- ration of the powder particles to a value which is necessary for the required average particle size, and removing and drying the resulting pellets. A drug which contains the active ingredient in the form of such pellets, with or without slowing of release, is also described.

Affiliated with

Also associated with

Rating

The production of pellets composed of an ephedrine derivative does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with The production of pellets composed of an ephedrine derivative, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and The production of pellets composed of an ephedrine derivative will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1899809