The production of solid drug forms

A - Human Necessities – 61 – J

Patent

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A61J 3/06 (2006.01) A61K 9/20 (2006.01)

Patent

CA 2209943

Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.

Des produits médicamenteux sous forme solide sont produits en mélangeant et en faisant fondre au moins un liant polymérique pharmacologiquement acceptable et au moins un ingrédient pharmaceutique actif, avec ou sans adjuvants pharmaceutiques traditionnels, en l'absence d'un solvant pour donner un mélange plastique et en donnant au mélange la forme médicamenteuse voulue par extrusion, la mise en forme se faisant en deux étapes, l'extrudat étant fractionné en articles formés dans une première étape et ces articles formés étant arrondis dans une seconde étape à l'état plastique.

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