The proliferation of cell-inhibiting peptide and its use

Details The proliferation of cell-inhibiting peptide and its use The proliferation of cell-inhibiting peptide and its use

C - Chemistry, Metallurgy

07

K

C07K 5/087 (2006.01) A61K 38/06 (2006.01) A61K 38/08 (2006.01) C07K 7/06 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2281033

The invention relates to the use of a peptide with the sequence Z-Phe-X-Gly-Y or a mixture of said peptides to manufacture a drug for the therapeutic treatment of the human or animal body, especially in cases of diseases involving malign cell growth or diseases with antigen-specific cell immune reactions, wherein Z is an N-terminal protective group or hydrogen, X is a natural amino acid and Y is carboxyl-OH or a synthetic cleavage related C- terminal group or an oligopeptide from natural amino acids. The invention also relates to novel peptides for such uses.

L'invention a pour objet l'utilisation d'un peptide de séquence Z-Phe-X-Gly-Y ou d'un mélange de tels peptides pour la fabrication d'un médicament destiné au traitement thérapeutique du corps humain ou animal, en particulier dans le cas d'affections impliquant une croissance de tumeurs malignes dans les cellules ou d'affections avec réactions immunitaires spécifiques d'antigènes des cellules, séquence dans laquelle Z désigne un groupe protecteur N-terminal ou l'hydrogène, X désigne un acide aminé naturel, et Y désigne un carboxyl-OH ou un groupe C-terminal résultant d'un dédoublement de synthèse ou un oligopeptide provenant d'acides aminés naturels. L'invention concerne également de nouveaux peptides pour de telles utilisations.

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