A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) C07K 19/00 (2006.01)
Patent
CA 2418179
The invention relates to a method of treating neuronal apoptosis in a mammal using nucleic acid encoding HSV-2 ICP10PK, or a polypeptide encoded thereby. The invention further relates to a method of treating neuronal apoptosis in a mammal using ICP10PK in combination with a nucleic acid encoding bcl-2, or the polypeptide encoded thereby. The invention also relates to the use of ICP10PK and ICP10PK in combination with bcl-2 to treat non-neuronal diseases characterized by apoptosis.
La présente invention concerne un procédé pour traiter l'apoptose neuronale chez un mammifère par utilisation, soit d'un acide nucléique codant l'ICP10PK du HSV-2, soit d'un polypeptide codé de cette façon. L'invention concerne également un procédé pour traiter l'apoptose neuronale chez un mammifère par utilisation d'ICP10PK en association avec un acide nucléique codant bcl-2, ou du polypeptide codé de cette façon. L'invention concerne aussi l'utilisation d'ICP10PK seul ou associé à bcl-2 pour traiter des affections non neuronales caractérisées par l'apoptose.
Aurelian Laure
Perkins Dana
Smith Cynthia
Johnson Ernest Peter
University Of Maryland Baltimore
LandOfFree
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