C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 14/725 (2006.01) C07K 16/28 (2006.01) C12N 15/62 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2316769
The invention generally relates to compositions and methods for identifying and testing tyrosine kinase signaling pathway agonists and antagonists, and more particularly, methods and compositions for screening compounds and identifying compounds that will modulate the interaction of protein tyrosine kinase substrates with their intracellular ligands, as well as between their intracellular ligands and other members of the signaling pathway.
L'invention se rapporte de manière générale à des compositions et à des méthodes permettant d'identifier et de vérifier des agonistes et antagonistes de la voie de signalisation des tyrosine-kinases. Elle se rapporte plus particulièrement à des méthodes et compositions permettant d'analyser et d'identifier des composés qui modulent l'interaction des substrats de tyrosine-kinases avec leurs ligands intracellulaires, ainsi qu'entre leurs ligands intracellulaires et d'autres membres de la voie de signalisation.
Samelson Lawrence E.
Zhang Weiguo
Department O. F. Health And Human Services The United States Of America Represented By The Secretary
Smart & Biggar
LandOfFree
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