A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/505 (2006.01) A61P 35/00 (2006.01) C07D 223/12 (2006.01) C07D 233/50 (2006.01) C07D 239/14 (2006.01) C07D 243/04 (2006.01) C07D 401/12 (2006.01)
Patent
CA 2510050
The present invention relates to a class of compounds represented by the Formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula (I), and methods of selectively inhibiting or antagonizing the .alpha.V.beta.3 and/or the .alpha.V .beta.5 integrin without significantly inhibiting the .alpha.V .beta.6 integrin
La présente invention concerne une classe de composés représentés par la formule (I) ou un sel pharmaceutiquement acceptable de ces derniers, des compositions pharmaceutiques comprenant les composés de formule (I), ainsi que des méthodes d'inhibition ou d'antagonisation sélective de l'intégrine .alpha.<SB>V</SB>.beta.¿3? et/ou .alpha.<SB>V</SB>.beta.¿5? sans inhibition significative de l'intégrine .alpha.<SB>V</SB>.beta.¿6?.
Collins Joe T.
Devadas Balekurdu
Lu Hwang-Fun
Malecha James
Marrufo Laura D.
Osler Hoskin & Harcourt Llp
Pharmacia Corporation
LandOfFree
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