The resolution of 5-methyltetrahydrofolic acid

C - Chemistry – Metallurgy – 07 – D

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C07D 475/04 (2006.01)

Patent

CA 2121351

Described is a method of preparing (6S)-5-methyl-tetrahydrofolic acid by separation of the racemic mixture, (6R,S)-5-me- thyl-tetrahydrofolic acid, using a based characterized in that N-ethyl-Z- aminomethylpyrrolidine or one of its optical isomers is used as the base.

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