The resolution of racemic verapamil

Details The resolution of racemic verapamil The resolution of racemic verapamil

C - Chemistry, Metallurgy

07

C

C07C 255/43 (2006.01) C07C 253/34 (2006.01)

Patent

CA 2122254

The method proposed for separating racemates of verapamil is characterized in that the free base of the compound is reacted with optically active dibenzoyltartaric acid or ditoluoyltartaric acid in the molar ratio 1:1 to 1:2 in a mixture of methanol and water in the ratio 1:1 to 3:1 or in a mixture of acetone and water in the ratio 0.5:1 to 2:1, the diastereomeric mixture thus obtained is separated by crystallization, the diastereomers subsequently converted into their respective free bases and these optionally converted into their salts with physiologically tolerated acids.

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