The retrovirus siv cpz-ant and its uses

Details The retrovirus siv cpz-ant and its uses The retrovirus siv cpz-ant and its uses

C - Chemistry, Metallurgy

12

N

C12N 7/00 (2006.01) A61K 39/21 (2006.01) C07H 21/00 (2006.01) C07K 14/155 (2006.01) C07K 16/10 (2006.01) C12N 5/18 (2006.01) C12N 15/49 (2006.01) C12P 21/08 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01) G01N 33/577 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2085370

2085370 9119785 PCTABS00008 The present invention relates to a retrovirus isolated from a chimpanzee and designated as SIVcpz-ant and to variants of this virus, having the following essential morphological and immunological properties: the virus exhibits a tropism for T4 lymphocytes, the virus exhibits no typical cytopathic effect with the formation of giant cells in the lymphocytes that it infects, the virus has a diameter of approximately 130 nm, the virus possesses a magnesium dependant reverse transcriptase activity, it can be cultivated in T4 receptor-bearing immortalized cell-lines, lysates of the virus contain a p27 protein that is immunologically distinct from the p25 of HIV-1 and p19 protein of HTLV-1 on western blot, lysates of the virus contain a gp140 protein which is immunologically distinct from the gp120 of HIV-1 and gp-110 of HTLV-I by western blot analysis, the lysate of the virus contains in addition a transmembrane glycoprotein with a molecular weight of 44.000 to 50.000 KD.

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