The secreted protein ccdc80 regulates adipocyte differentiation

Details The secreted protein ccdc80 regulates adipocyte differentiation The secreted protein ccdc80 regulates adipocyte differentiation

A - Human Necessities

61

K

A61K 38/17 (2006.01) A61K 31/7088 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) C12Q 1/00 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2677818

Disclosed herein are methods of modulating adipogenesis. The methods include contacting a cell expressing the Ccdc80 gene with an agent that modulates the expression or activity of the Ccdc80 gene or Ccdc80 protein. Further disclosed herein are methods of treating conditions such as obesity, insulin resistance, and/or type 2 diabetes with Ccdc80 modulators. Also disclosed herein are methods of identifying Ccdc80 modulators.

La présente invention concerne des procédés de modulation de l'adipogenèse. Ces procédés comprennent la mise en contact d'une cellule exprimant le gène Ccdc80 avec un agent modulant l'expression ou l'activité du gène Ccdc80 ou de la protéine Ccdc80. La présente invention concerne, en outre, des procédés de traitement d'affections telles que l'obésité, la résistance à l'insuline et/ou le diabète de type 2 au moyen de modulateurs du gène ou de la protéine Ccdc80. La présente invention concerne, encore, des procédés d'identification des modulateurs du gène ou de la protéine Ccdc80.

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