C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/67 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2309535
The present invention is directed to a DNA element that enhances the translation of the human amyloid precursor protein (APP) gene. The enhancer may be incorporated into expression vectors to enhance recombinant protein production. In addition, the invention is directed to an assay that utilizes vectors containing the translation enhancer element for the purpose of identifying agents that modulate the expression of the human amyloid precursor protein. These agents will ultimately be used to suppress APP expression in patients with Alzheimer's disease.
L'invention concerne un élément d'ADN qui amplifie la traduction du gène de la protéine précurseur amyloïde humaine (APP). L'amplificateur peut être incorporé en vecteurs d'expression pour amplifier la production de protéines recombinantes. L'invention concerne en outre un dosage qui utilise des vecteurs contenant l'élément amplificateur de traduction permettant d'identifier des agents qui modulent l'expression de la protéine précurseur amyloïde humaine. Ces agents sont utilisés pour supprimer l'expression APP chez les patients atteints de la maladie d'Alzheimer.
Brigham And Women's Hospital Inc.
Smart & Biggar
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