The treatment of hiv and other viral infections using...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61K 31/513 (2006.01) A61K 31/7072 (2006.01) A61K 38/19 (2006.01) A61K 38/21 (2006.01) A61P 31/18 (2006.01) C07K 14/16 (2006.01)

Patent

CA 2224008

Novel antiviral combinations for the treatment or prevention of viral infections, in particular, HIV, are disclosed. This new antiviral therapy employs either DP-178 or DP-107, viral fusion inhibitors, in combination with at least one other antiviral therapeutic agent. The combinations of the invention are better than single therapies alone, and in certain cases are synergistic. The use of DP-178 or DP-107 is an ideal therapy to combine with another antiviral, given both the novel mechanism which this therapeutic blocks HIV transmission and the non-toxicity of the therapeutic.

La présente invention concerne des combinaisons antivirales destinées au traitement ou à la prévention d'infections virales, et en particulier par le VIH. Cette nouvelle thérapie antivirale recourt soit au DP-178, soit au DP-107, à des inhibiteurs de fusion de virus, en combinaison avec au moins un autre agent thérapeutique antiviral. Les combinaisons de l'invention, constituant une amélioration par rapport aux simples monothérapies, présentent dans certains cas des effets de synergie. L'utilisation de DP-178 ou de DP-107 constitue une thérapie idéale à combiner avec un autre antiviral, étant donné que le principe nouveau selon lequel cette thérapie bloque la transmission du VIH et la non-toxicité de cette thérapie.

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