The treatment of inflammatory disorders and pain

Details The treatment of inflammatory disorders and pain The treatment of inflammatory disorders and pain

C - Chemistry, Metallurgy

07

C

C07C 215/10 (2006.01) A61K 31/133 (2006.01) A61P 19/00 (2006.01)

Patent

CA 2613905

A compound that is useful for the treatment or prevention of a condition such as pain, that is associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, is of formula (I) wherein R1 is aryl or heteroaryl optionally substituted with R5; R2 is H, alkyl or CH2OH and can be part of a ring with R4; R3 is H, alkyl or CH2OH and can be part of a ring with R4; R4 is H or alkyl or CH2 (when forming part of a ring with R2 or R3); and R5 is alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, F, Cl, Br, I, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, CH2OH or OCONalkyl2; or a salt thereof.

L'invention concerne un composé qui est utile dans le traitement ou la prévention d'une affection telle qu'une douleur, qui est associée à la prolifération de cellules T ou qui est provoquée par des cytokines pro- et/ou anti-inflammatoires, selon la formule (I) dans laquelle R1 est un aryle ou un hétéroaryle éventuellement substitué par R5 ; R2 est H, un alkyle ou CH2OH et peut faire partie d'un anneau avec R4 ; R3 est H, un alkyle ou CH2OH et peut faire partie d'un anneau avec R4 ; R4 est H ou un alkyle ou CH2 (lorsqu'il constitue un anneau avec R2 ou R3) ; et R5 est un alkyle, CF3, OH, Oalkyle, OCOalkyle, CONH2, CN, F, Cl, Br, I, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyle, CONH2, SOMe, CH2OH ou OCONalkyle2 ; ou un sel de ceux-ci.

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