The treatment of inflammatory disorders and pain

Details The treatment of inflammatory disorders and pain The treatment of inflammatory disorders and pain

A - Human Necessities

61

K

A61K 31/137 (2006.01) A61K 31/138 (2006.01) A61K 31/37 (2006.01) A61K 31/4458 (2006.01) A61K 31/4704 (2006.01) A61P 1/00 (2006.01) A61P 1/02 (2006.01) A61P 11/06 (2006.01) A61P 11/08 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/02 (2006.01) A61P 29/02 (2006.01)

Patent

CA 2579540

Compounds that may be used for the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro-inflammatory cytokines are of formula (I): wherein R1 is CHR4-OR5 or CHR4-SR5, or aryl or heteroaryl optionally substituted with one or more groups R6; R2 is alkyl or is part of a ring with R3; R3 is H, alkyl or CH2 (when forming part of a ring with R2); R4 is H or alkyl or is part of a ring with R5; R5 is aryl or heteroaryl optionally substituted with R7; each R6 is independently alkyl, CF3, OH, Oalkyl, OCOalkyl, CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyl, CONH2, SOMe, SO2NH2, Salkyl, CH2SO2alkyl or OCONalkyl2; R7 is R8 or (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogen, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryl, NHSO2Me, CONH2, SMe, SOMe or SO2NH2; R8 is (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 or (CH2)nCOaryl; R9 is alkyl or cycloalkyl; and n is 1 to 4; or a salt thereof, including clenbuterol and atenolol.

L'invention concerne des composés pouvant être utilisés pour traiter ou prévenir un état associé à la prolifération des lymphocytes T ou induit par des cytokines pro-inflammatoire représentés par la formule (I). Dans cette formule, R1 représente CHR4-OR5 ou CHR4-SR5, ou aryle ou hétéroaryle éventuellement substitué par un ou plusieurs groupes R6; R2 représente alkyle ou une partie de noyau avec R3; R3 représente H, alkyle ou CH2 (lorsqu'il forme une partie avec un noyau R2); R4 représente H ou alkyle ou une partie de noyau avec R5; R5 représente aryle ou hétéroaryle éventuellement substitué par R7; chaque R6 représente indépendamment alkyle, CF3, OH, Oalkyle, OCOalkyle, CONH2, CN, halogène, NH2, NO2, NHCHO, NHCONH2, NHSO2alkyle, CONH2, SOMe, SO2NH2, Salkyle, CH2SO2alkyle ou OCONalkyle2; R7 représente R8 ou (CH2)nOR8, R9, CF3, OH, OR9, OCOR9, COR9, COOR9, CONH2, CH2CONH2, CN, halogène, NH2, NO2, NHCHO, NHCONH2, NHCONHR7, NHCON(R9)2, NHCOR9, NHCOaryle, NHSO2Me, CONH2, SMe, SOMe ou SO2NH2; R8 représente (CH2)nOR9, (CH)nOR9, (CH2)nCOOR9 ou (CH2)nCOaryIe; R9 représente alkyle ou cycloalkyle; et n est compris entre 1 e 4. L'invention concerne également un sel desdits composés.

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