A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/137 (2006.01) A61P 1/00 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 17/06 (2006.01) A61P 19/02 (2006.01) A61P 19/10 (2006.01) A61P 25/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2558126
A compound (preferably bufeniode, denopamine, fenoterol, ifenprodil, isoxsuprine, labetol, medroxalol, mesuprine, nylidrin, protokylol, ractopamine, ritodrine, salmefamol or sulfinalol) that has utility in the treatment or prevention of a condition associated with T-cell proliferation or that is mediated by pro- and/or anti-inflammatory cytokines, and in particular a disease selected from the group consisting of rheumatoid arthritis, osteoarthritis, or osteoporosis, chronic demyelinating disease such as multiple sclerosis, respiratory diseases such as asthma or chronic obstructive pulmonary disease, inflammatory bowel disease (IBD) such as ulcerative colitis or Crohn~s disease, dermatological conditions such as psoriasis, scleroderma or atopic dermatitis, dental diseases such as periodontal disease or gingivitis, diabetic nephropathy, lupus nephritis, IgA nephropathy or glomerulonephritis, systemic iupus erythomatosus (SLE), graft vs host disease, a pain condition, is of formula (I), wherein R1 is H or Me; R2 is H or alkyl and R3 is H or Me, or R2 and R3 are -CH2- thereby forming a ring; n is 0 to 2; X is CH2 or O; and the two benzene rings are each optionally substituted with OH, OMe, halogen, NHCHO, NHSO2Me, CONH2, SOMe, OCH2O, or CH2OH.
Cette invention se rapporte à un composé, qui est utile dans le traitement ou la prévention d'un état associé à la prolifération des lymphocytes T ou médié par des cytokines pro-inflammatoires et/ou anti-inflammatoires, et qui est représenté par la formule (I), dans laquelle R1 représente H ou Me; R2 représente H ou alkyle et R3 représente H ou Me, ou alors R2 et R3 représentent -CH2- formant ainsi un cycle; n est égal à un nombre compris entre 0 et 2; X représente CH2 ou O ; et les deux cycles de benzène sont éventuellement chacun substitués par OH, OMe, halogène, NHCHO, NHSO2Me, CONH2, SOMe, OCH2O ou CH2OH.
Baxter Andrew Douglas
Brew John
Sosei R&d Ltd.
Torys Llp
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