The use of 1-aminocyclohexane derivatives to modify...

Details The use of 1-aminocyclohexane derivatives to modify... The use of 1-aminocyclohexane derivatives to modify...

A - Human Necessities

61

K

A61K 31/13 (2006.01)

Patent

CA 2540921

The invention relates to the use of NMDA receptor antagonists such as 1- aminocyclohexane derivatives to modify deposition of potentially toxic and fibrillogenic A.szlig. peptides in amyloidopathies. Specifically, the invention relates to the ability of memantine to intervene in the processing of APP and decrease the levels of fibrillogenic A.szlig. peptides.

L'invention se rapporte à l'utilisation d'antagonistes des récepteurs NMDA, tels que des dérivés de 1-aminocyclohexane, pour modifier le dépôt de peptides A.beta. fibrillogènes et potentiellement toxiques dans des amyloïdopathies. L'invention se rapporte spécifiquement à la capacité de la mémantine à jouer un rôle dans le traitement de l'APP et à réduire les taux de peptides A.beta. fibrillogènes.

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