The use of a 3895 bp mitochondrial dna deletion as a marker...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2480184

A method for detecting the genesis and progression of UV damage to the skin. This invention is related to the field of mitochondrial genomics. In particular it is related to deletions in the mitochondrial genome, in particular the 3895 by deletion of the minor arc. The deletion can be used as an indicator of the genesis and progression of UV damage to skin, for example skin cancer, and in particular non-melanoma skin cancer (NMSC).

L'invention porte sur une méthode permettant de détecter l'apparition et l'évolution de lésions cutanées causées par des UV. Cette invention se rapporte au domaine de la génomique mitochondriale. En particulier, elle porte sur des délétions ayant lieu dans le génome mitochondrial, plus précisément en position 3895 par une délétion de l'arc mineur. La délétion peut servir d'indicateur de l'apparition de lésions cutanées attribuables à des UV, par exemple un cancer de la peau, et en particulier un cancer de la peau de type non mélanome.

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