The use of an ox-2 protein or nucleic acid in immunomodulation

Details The use of an ox-2 protein or nucleic acid in immunomodulation The use of an ox-2 protein or nucleic acid in immunomodulation

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2308765

Methods and compositions for inducing immune suppression are disclosed. The methods involve administering an effective amount of an OX-2 protein or a nucleic acid encoding an OX-2 protein. The methods are useful in preventing graft rejection, fetal loss, autoimmune disease, and allergies. Methods and compositions for preventing immune suppression are also disclosed. The methods involve administering an effective amount of an agent that inhibits OX-2.

Cette invention concerne des procédés et des compositions permettant d'induire une immunodépression. Ces procédés consistent à administrer une dose efficace de protéine OX-2 ou un acide nucléique codant pour une protéine OX-2. Ils conviennent particulièrement pour prévenir les rejets de greffes, les pertes fotales ainsi que les maladies auto-immunes et les allergies. L'invention porte également sur des techniques et des compositions permettant d'éviter une immunosuppression. Ces procédés comportent l'administration d'une dose efficace d'un agent inhibant la protéine OX-2.

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