The use of angiotensin i derivative as an agent for the...

A - Human Necessities – 61 – K

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A61K 38/08 (2006.01) A61K 38/55 (2006.01) A61P 9/10 (2006.01) F24J 1/00 (2006.01)

Patent

CA 2452043

The present invention relates generally to a method for the treatment and/or prophylaxis of infarction-related cardiac injuries and disorders. More particularly, the present invention contemplates a method for the treatment and/or prophylaxis of myocardial infarction and heart failure and/or related conditions. The method of the present invention is practised by the administration of a derivative of angiotensin I. In a preferred embodiment, the angiotensin I is des-Aspartate-angiotensin I. The present invention further contemplates compositions for use in the treatment and/or prophylaxis of infarction-related cardiac injuries and disorders such as but not limited to myocardial infarction and heart failure.

L'invention concerne de manière générale une méthode permettant le traitement et/ou la prévention des lésions et des troubles cardiaques de type infarctus. L'invention concerne plus particulièrement une méthode de traitement et/ou de prévention de l'infarctus du myocarde et de l'insuffisance cardiaque et/ou de pathologies voisines. Cette méthode comprend l'administration d'un dérivé d'angiotensine I. Dans une forme de réalisation préférée, cette angiotensine I est de préférence la des-asparatate-angiotensine I. L'invention concerne en outre des compositions destinées au traitement et/ou à la prévention des lésions et troubles cardiaques de type infarctus, notamment, mais non exclusivement, l'infarctus du myocarde et l'insuffisance cardiaque.

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