A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4402 (2006.01) A61K 31/138 (2006.01) A61K 31/426 (2006.01) A61K 31/428 (2006.01) A61K 31/445 (2006.01) A61K 31/4535 (2006.01) A61K 31/495 (2006.01) A61K 31/5415 (2006.01) A61P 9/12 (2006.01)
Patent
CA 2690483
The invention concerns a novel histamine receptor antagonist and the use of an histamine receptor antagonist for the reduction of intracranial pressure (ICP), in particular for the prevention and treatment of elevated intracranial pressure and/or secondary ischaemia, in particular caused by brain injury, more in particular caused by traumatic (TBI) and non--traumatic brain injury. The novel compounds comprise compounds according to the general Formula (I) the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N-oxide form thereof. In particular, the preferred compound is 3-[2-[4-(11,12-dihydro-6H-benzimidazo[2,1--b] [3]benzazepine-6-yl)-2-(phenylmethyl)-1-piperidinyl]ethyl]-2,10-dimethyl pyrimido[1,2-.alpha.]benzimidazol-4(10H)-one, the pharmaceutically acceptable acid or base addition salts thereof, the stereochemically isomeric forms thereof and the N- oxide form thereof. Also claimed is the novel use of commercially available histamine H1- and H2--receptor antagonists for the reduction of intracranial pressure (ICP).
Alcazar-Vaca Manuel Jesus
Bartolome-Nebreda Jose Manuel
Fernandez-Gadea Francisco Javier
Gomez-Sanchez Antonio
Janssens Frans Eduard
Gowling Lafleur Henderson Llp
Janssen Pharmaceutica N.v.
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