The use of bacillus pb6 for the prophylaxis or treatment of...

C - Chemistry – Metallurgy – 12 – N

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C12N 1/20 (2006.01) A61K 31/733 (2006.01) A61K 35/74 (2006.01) A61P 1/00 (2006.01)

Patent

CA 2631289

Bacteria of the sp. Bacillus that produce a lipopeptide are found to be effective in the treatment and prophylaxis of gastro-intestinal disease when administered as a probiotic. In particular, a strain of Bacillus bacteria identified as PB6 is useful for the treatment of Antibiotic Associated Diarrhea (AAD) or the more serious condition Clostridium difficile associated diarrhea (CDAD) when administered as a probiotic. Additionally, these bacteria have been found efficient for the treatment of immunorelated diseases such as Inflammatory Bowel Disease (IBD).

On a découvert que les bactéries du sp. Bacillus, qui produisent un lipopeptide, étaient efficaces pour prévenir et traiter une maladie gastro-intestinale lorsqu'on les administre sous forme de probiotique. On utilise en particulier une souche de bactéries Bacillus identifiées comme étant PB6 pour traiter une diarrhée associée à l'administration d'un antibiotique (AAD) ou la diarrhée plus sévère associée à Clostridium difficile (CDAD), laquelle souche est administrée sous forme de probiotique. On a, en outre, découvert que ces bactéries étaient efficaces pour traiter des maladies liées à l'immunité, telles que les maladies intestinales inflammatoires (IBD).

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