G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/48 (2006.01) A61K 45/00 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2500886
The present invention relates to the use of cardiac hormones, particularly natriuretic peptides, for assessment of risk of suffering from a cardiovascular complication, particularly heart disease or acute coronary syndrome, as a consequence of intravasal volume overload. In particular, the invention relates to a method for diagnosing the risk of a patient whose intravasal volume is increased or will be increased of suffering from a cardiovascular complication as a consequence of the increase of intravasal volume, comprising the steps of (a) taking a body fluid or tissue sample, and (b) measuring, preferably in vitro, the level of a cardiac hormone. The most preferred cardiac hormone in the context of the present invention is NT-proBNP.
La présente invention concerne l'utilisation d'hormones cardiaques, particulièrement de peptides natriurétiques, pour l'évaluation du risque de complication cardiovasculaire, particulièrement de cardiopathie ou de syndrome coronarien aigu, découlant d'un surplus de volume intravasal. Plus particulièrement, l'invention concerne une méthode pour diagnostiquer le risque qu'a un patient dont le volume intravasal a augmenté ou augmentera de présenter une complication cardiovasculaire découlant de l'augmentation du volume intravasal, laquelle comprend les étapes suivantes : a) prélèvement d'un échantillon de liquide organique ou de tissu; et b) mesure, de préférence in vitro, de la concentration d'une hormone cardiaque. L'hormone cardiaque de choix dans le contexte de la présente invention est NT-proBNP.
Hess Georg
Horsch Andrea
Borden Ladner Gervais Llp
F. Hoffmann-La Roche Ag
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