C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/90 (2006.01) C12N 5/10 (2006.01) C12N 15/10 (2006.01) C12Q 1/68 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2314246
The invention relates to compositions and methods for targeting sequence modifications in one or more genes of a related family of genes using enhanced homologous recombination techniques. The invention also relates to compositions and methods for isolating and identifying novel members of homologous sequence families. These techniques may be used to create animal or plant models of disease as well as to identify new targets for drug or pathogen screening.
L'invention concerne des compositions et méthodes de ciblage de modifications de séquences dans un ou plusieurs gènes d'une famille de gènes liée, grâce à des techniques améliorées de recombinaison d'homologues. L'invention concerne également des compositions et méthodes d'isolement et d'identification de nouveaux membres de familles à séquences homologues. On peut utiliser ces techniques pour créer des modèles de maladies d'animaux ou de plantes ainsi que pour identifier de nouvelles cibles de criblage de médicaments ou d'agents pathogènes.
Lehman Christopher W.
Pati Sushma
Zarling David
Zeng Hong
Napro Biotherapeutics Inc.
Pangene Corporation
Riches Mckenzie & Herbert Llp
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