The use of cytokine able to bind il-18bp and of inhibiting...

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/19 (2006.01) A61K 38/20 (2006.01)

Patent

CA 2500577

The present invention relates to the use of a cytokine-1, preferably from the IL-1 family more preferably IL-1F7b, or an isoform, mutein, fused protein, functional derivative or fragment thereof, capable of binding to IL-18 BP or a mutein, fused protein, functional derivative or fragment thereof and capable of inhibiting a receptor of a cytokine-2, cytokine-2 being a member of the IL- 1 family, preferably IL-18, in the manufacture of a medicament for the treatment or prevention of a disease which is caused or aggravated by inducing said receptor of cytokine-2.

L'invention se rapporte à l'utilisation d'une cytokine-1, de préférence de la famille IL-1 et mieux encore, de la famille IL-1F7b, ou d'un isoforme, d'une mutéine, d'une protéine fusionnée, d'un dérivé fonctionnel ou d'un fragment de celui-ci, pouvant se fixer à IL-18 BP ou d'une muteine, d'une protéine fusionnée, d'un dérivé fonctionnel ou d'un fragment de celui-ci pouvant inhiber un récepteur de cytokine-2, cytokine-2 étant un élément de la famille IL-1, de préférence IL-18, dans la production d'un médicament pour le traitement ou pour la prévention d'une maladie provoquée ou aggravée par induction dudit récepteur de cytokine-2.

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