The use of dead cell material obtained from rhodamine-based...

A - Human Necessities – 61 – K

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A61K 41/00 (2006.01) A61K 35/04 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) A61N 5/06 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2548468

The present invention relates to the use of PDT-treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of vaccines for immunoprotection or immunomodulation. More particularly, the use of PDT- treated cells (whole or fragments thereof) and/or supernatant thereof in the preparation of an immunologic compound for prevention, protection, prophylaxis or treatment of an immunological disorder, infection and/or a cancer in an individual, which comprises treatment of the individual cells or components thereof with a photoactivatable molecule selected from the group consisting of compounds I to XVIII, wherein the photoactivatable molecule is activated by a light of appropriate wavelength, thereby activating the photoactivatable molecule and causing prevention, protection, prophylaxis or treatment of the immunological disorder, infection and/or a cancer.

La présente invention concerne l'utilisation de cellules (cellules entières ou fragments de cellules) traitées par TPD et/ou de leur surnageant dans la préparation de vaccins destinés à l'immunoprotection ou à l'immunomodulation. La présente invention concerne plus précisément l'utilisation de cellules (cellules entières ou fragments de cellules) traitées par TPD et/ou de leur surnageant dans la préparation d'un composé immunologique destiné à la protection, à la prévention ou au traitement d'un trouble immunologique, d'une infection et/ou du cancer chez un individu. L'invention consiste à traiter les cellules individuelles ou des composants de ces cellules à l'aide d'une molécule photoactivable sélectionnée dans le groupe comprenant les composés I à XVIII, la molécule photoactivable étant activée à l'aide d'une lumière de longueur d'onde adaptée permettant d'activer la molécule photoactivable et, ainsi, de protéger, de prévenir ou de traiter le trouble immunologique, l'infection et/ou le cancer.

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