The use of epidermal growth factor as a gastrointestinal...

Details The use of epidermal growth factor as a gastrointestinal... The use of epidermal growth factor as a gastrointestinal...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A23K 1/16 (2006.01)

Patent

CA 2492724

New utilities for epidermal growth factor (EGF) as a gastrointestinal therapeutic agent are described. In particular, EGF is useful in preventing gastrointestinal colonization by pathogens and in promoting weight gain. As such EGF can be used to treat intestinal infections and increase animal production for example in the agriculture or aquaculture industry. EGF is also useful in increasing the intestinal absorption of immunoglobulins. Inhibition of the epidermal growth factor signaling cascade may be used to prevent uptake of toxic or adverse compounds or to promote weight loss. Therefore, the use of an agent that inhibits the activity of epidermal growth factor to decrease the absorption of substance or decrease weight gain is also described.

Nouvelles utilisations du facteur de croissance épidermique (EGF) comme agent thérapeutique gastro-intestinal. En particulier, l'EGF est utile pour prévenir la colonisation gastro-intestinale par des pathogènes et pour favoriser le gain pondéral. L'EGF peut donc être utilisé pour traiter les infections intestinales et pour augmenter la production animale, par exemple dans l'industrie agricole ou aquicole. L'EGF permet aussi d'accroître l'absorption intestinale des immunoglobulines. L'inhibition de la cascade de signalisation du facteur de croissance épidermique peut servir à prévenir l'absorption de composés toxiques ou nocifs ou à favoriser la perte de poids. Par conséquent, est également décrite l'utilisation d'un agent qui inhibe l'activité du facteur de croissance épidermique dans le but de diminuer l'absorption de substances ou de réduire le gain pondéral.

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