The use of epidermal growth factor as a gastrointestinal...

Details The use of epidermal growth factor as a gastrointestinal... The use of epidermal growth factor as a gastrointestinal...

A - Human Necessities

61

K

A61K 38/18 (2006.01) A23K 1/16 (2006.01) A23K 1/165 (2006.01) A61K 31/277 (2006.01)

Patent

CA 2220434

New utilities for epidermal growth factor (EGF) as a gastrointestinal therapeutic agent are described. In particular, EGF is useful in preventing gastrointestinal colonization by pathogens and in promoting weight gain. As such EGF can be used to treat intestinal infections and increase animal production for example in the agriculture or aquaculture industry. EGF is also useful in increasing the intestinal absorption of immunoglobulins. Inhibition of the epidermal growth factor signalling cascade may be used to prevent uptake of toxic or adverse compounds or to promote weight loss. Therefore, the use of an agent that inhibits the activity of epidermal growth factor to decrease the absorption of substance or decrease weight gain is also described.

L'invention décrit de nouvelles possibilités d'utilisation du facteur de croissance de l'épiderme (EGF) comme agent thérapeutique gastro-intestinal. L'EGF est notamment utile pour prévenir la colonisation gastro-intestinale par des agents pathogènes et favoriser la prise de poids. En tant que tel, l'EGF peut être utilisé pour traiter des infections intestinales et accroître la production animale, par exemple dans le domaine agricole ou aquacole. L'EGF est également utile pour accroître l'absorption intestinale des immunoglobulines. Il est possible d'avoir recours à l'inhibition de la cascade de signalisation du facteur de croissance de l'épiderme pour empêcher la fixation de composés toxiques ou nocifs ou pour favoriser la perte de poids. Par conséquent, l'invention décrit également l'utilisation d'un agent inhibant l'activité du facteur de croissance de l'épiderme pour réduire l'absorption de substance ou la prise de poids.

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