C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) A61K 31/7088 (2006.01) A61K 38/16 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) C07K 14/395 (2006.01) C07K 14/47 (2006.01) C12N 15/11 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2538495
The present invention relates to the significant functional role of several C. elegans genes and of their corresponding gene products in chromatin separation during cell division that could be identified by means of RNA-mediated interference (RNAi) and to the identification and isolation of functional orthologs of said genes including all biologically functional derivatives thereof. The invention further relates to the use of said genes and gene products (including said orthologs) in the development or isolation of anti - proliferative agents, particularly their use in appropriate screening assays, and their use for diagnosis and treatment of proliferative and other diseases. In particular, the invention relates to the use of small interfering RNAs derived from said genes for the treatment of proliferative diseases.
L'invention concerne le rôle fonctionnel important de plusieurs gènes de C. elegans et des produits géniques correspondants dans la séparation de la chromatine au cours de la division cellulaire, qui a pu être identifié grâce à l'interférence ARN (iARN) et à l'identification et l'isolement d'orthologues fonctionnels desdits gènes, y compris tous leurs dérivés biologiquement fonctionnels. L'invention concerne en outre l'utilisation de ces gènes et produits géniques (y compris lesdits orthologues) pour la mise au point ou l'isolement d'agents antiprolifératifs, en particulier leur utilisation dans des techniques de criblage appropriées ainsi que dans le diagnostic et le traitement, entre autres, de maladies prolifératives. Elle concerne en particulier l'utilisation de petits ARN interférents obtenus à partir desdits gènes pour traiter des maladies prolifératives.
Echeverri Christophe
Goenczy Pierre
Hyman Anthony
Jones Steven
Koski Liisa
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Cenix Bioscience Gmbh
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