The use of flt3 ligand to generate dendritic cells

Details The use of flt3 ligand to generate dendritic cells The use of flt3 ligand to generate dendritic cells

C - Chemistry, Metallurgy

12

N

C12N 5/0784 (2010.01) C12N 5/0783 (2010.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 39/00 (2006.01) A61K 39/39 (2006.01)

Patent

CA 2232865

Flt3-ligand can be used to generate large numbers of dendritic cells from hematopoietic progenitor and stem cells. Flt3-ligand can be used to augment immune responses in vivo, and expand dendritic cells ex vivo. Such dendritic cells can then be used to present tumor, viral or other antigens to naive T cells, can be useful as vaccine adjuvants.

L'association ligand-Flt3 peut servir à générer de grands nombres de cellules dendritiques à partir de cellules hématopoïétiques progénitrices et souches. L'association ligand-Flt3 peut servir à accroître les réactions immunitaires in vivo, et à répandre des cellules dendritiques ex vivo. Ces cellules dendritiques peuvent ensuite servir à présenter des antigènes tumoraux, viraux ou autres à des lymphocytes T naïfs et peuvent s'avérer utiles en tant qu'adjuvants de vaccins.

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