The use of fumaric acid derivatives for treating cardiac...

Details The use of fumaric acid derivatives for treating cardiac... The use of fumaric acid derivatives for treating cardiac...

A - Human Necessities

61

K

A61K 31/231 (2006.01) A61P 9/00 (2006.01) A61P 11/06 (2006.01)

Patent

CA 2526586

According to a first aspect the invention relates to the use of fumaric acid derivatives selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoalkyl ester salts, fumaric acid monoamides, monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment or prevention of cardiac insufficiency, in particular left ventricular insufficiency, myocardial infarction and angina pectoris. According to a second aspect the invention relates to the use of fumaric acid derivatives, selected from the group consisting of dialkyl fumarates, monoalkyl hydrogen fumarates, fumaric acid monoaklyl ester salts, fumaric acid monoamido fumaric acid salts, fumaric acid diamides, monoalkyl monoamido fumarates, carbocyclic and oxacarbocyclic oligomers of these compounds and mixtures thereof for preparing a drug for the treatment of asthma and chronic obstructive pulmonary diseases, especially asthma caused by allergies, infections, analgesics, job conditions or physical effort, mixed forms of asthma, or asthma cardiale.

Dans un premier aspect, l'invention concerne l'utilisation de dérivés d'acide fumarique choisis dans le groupe comprenant des fumarates dialcoylés, de fumarates d'hydrogène monoalkyliques, des sels d'ester monoalkylique d'acide fumarique, des monoamides d'acide fumarique, des sels monoamido d'acide fumarique, des diamides d'acide fumarique, des fumarates monoamido monoalkyliques, des oligomères carbocycliques et oxacarbocycliques de ces composés ainsi que des mélanges de ceux-ci pour préparer un médicament destiné au traitement ou à la prévention de l'insuffisance cardiaque, et plus spécifiquement de l'insuffisance ventriculaire gauche, de l'infarctus du myocarde et de l'angine de poitrine. Dans un deuxième aspect, l'invention concerne l'utilisation de dérivés d'acide fumarique choisis dans le groupe comprenant des fumarates dialcoylés, de fumarates d'hydrogène monoalkyliques, des sels d'ester monoalkylique d'acide fumarique, des monoamides d'acide fumarique, des sels monoamido d'acide fumarique, des diamides d'acide fumarique, des fumarates monoamido monoalkyliques, des oligomères carbocycliques et oxacarbocycliques de ces composés ainsi que des mélanges de ceux-ci pour préparer un médicament destiné au traitement de l'asthme et de maladies obstructrives resppiratoires chroniques, plus spécifiquement de l'asthme provoqué par des allergies, infections, analgésiques, conditions de travail ou effort physique, des formes mixtes d'asthme ou l'asthme cardial.

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