The use of growth hormone secretagogues to treat systemic...

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/437 (2006.01) A61K 31/00 (2006.01) A61K 31/438 (2006.01) A61K 31/444 (2006.01) A61K 31/4985 (2006.01) A61K 31/55 (2006.01) A61K 38/05 (2006.01) A61K 45/06 (2006.01) A61P 1/04 (2006.01) A61P 1/10 (2006.01)

Patent

CA 2350857

Disclosed are medicines for treating systemic lupus erythematosus and/or inflammatory bowel disease such as Crohn's disease or ulcerative colitis, which comprise a growth hormone secretagogue (GHS), prodrug thereof or a pharmaceutically acceptable salt of the GHS or the prodrug. More particularly, the GHS is a compound of the Formula I: (see formula I) (in which HET is a heterocyclic moiety; R3 is alkyl, etc.; R4 is H, alkyl, etc.; X4 is H or alkyl; R6 is bond, alkylene, etc.; R7 and R8 are each H, alkyl, etc.) or a prodrug thereof or a pharmaceutically acceptable salt of the GHS or the prodrug. Also disclosed are combinations of a GHS and a second therapeutic agent, where the second therapeutic agent is known to be beneficial in the treatment of systemic lupus erythematosus and/or inflammatory bowel disease such as Crohn's disease or ulcerative colitis; and kits and pharmaceutical compositions comprising such combinations.

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