The use of hdac inhibitors for the treatment of cancer

Details The use of hdac inhibitors for the treatment of cancer The use of hdac inhibitors for the treatment of cancer

A - Human Necessities

61

K

A61K 31/167 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2535806

The present invention relates to methods of treating cancers, e.g., mesothelioma or lymphoma. More specifically, the present invention relates to methods of treating mesothelioma or diffuse large B-cell lymphoma (DLBCL), by administration of pharmaceutical compositions comprising HDAC inhibitors, e.g., suberoylanilide hydroxamic acid (SAHA). The oral formulations of the pharmaceutical compositions have favorable pharmacokinetic profiles such as high bioavailability and surprisingly give rise to high blood levels of the active compounds over an extended period of time. The present invention further provides a safe, daily dosing regimen of these pharmaceutical compositions, which is easy to follow, and which results in a therapeutically effective amount of the HDAC inhibitors in vivo.

L'invention se rapporte à des procédés permettant de traiter des cancers, par exemple des mésothéliomes ou des lymphomes. Cette invention concerne de manière plus spécifique des procédés permettant de traiter des mésothéliomes ou des lymphomes B diffus à grandes cellules (DLBCL), par administration de compositions pharmaceutiques comprenant des inhibiteurs d'HDAC, par exemple de l'acide hydroxamique suberoylanilide (SAHA). Les formulations orales des compositions pharmaceutiques possèdent des profils pharmacocinétiques favorables: ils présentent une biodisponibilité élevée et entraînent, de manière surprenante, des concentrations élevées des composés actifs dans le sang sur un laps de temps étendu. La présente invention concerne également une posologie quotidienne sûre desdites compositions pharmaceutiques, qui est simple à appliquer et permet d'obtenir une quantité d'inhibiteurs d'HDAC thérapeutiquement efficace in vivo.

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