The use of histamine h4 receptor antagonist for the...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2471214

The present invention relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other disired modulation of inflammatory responses, inflammation, or diseases and/or conditions that are modulated, affected or caused by inflammation or inflammatory responses. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other disired modulation of polymorphonuclear leukocyte responses, such as migration to a particular site, or diseases and/or conditions that are modulated, affected or caused by polymorphonuclear leukocytes. The present invention also relates to the use of histamine H4 receptor modulators for the prevention, treatment, induction, or other desired modulation of mast cell responses, such as de-granulation, or diseases and/or conditions that are modulated, affected or caused by mast cells.

La présente invention concerne l'utilisation de modulateurs du récepteur H4 de l'histamine pour la prévention, le traitement, l'induction, ou toute autre modulation requise des réponses inflammatoires, de l'inflammation, ou des maladies et/ou autres états qui sont modulés, affectés ou provoqués par l'inflammation ou les réponses inflammatoires. La présente invention a également pour objet l'utilisation de modulateurs du récepteur H4 de l'histamine pour la prévention, le traitement, l'induction ou toute autre modulation requise des réponses des leucocytes polymorphonucléaires, comme la migration vers un site particulier, ou les maladies et/ou états qui sont modulés, affectés ou provoqués par les leucocytes polymorphonucléaires. La présente invention traite également de l'utilisation des modulateurs du récepteur H4 de l'histamine pour la prévention, le traitement, l'induction ou toute autre modulation requise des réponses des mastocytes, comme la dégranulation, ou les maladies et/ou états qui sont modulés, affectés ou provoqués par les mastocytes.

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