The use of inhaled gaseous nitric oxide as a mucolytic agent...

A - Human Necessities – 61 – M

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A61M 11/00 (2006.01) A61M 15/00 (2006.01) A61M 15/08 (2006.01) A61M 16/00 (2006.01) A62B 7/00 (2006.01)

Patent

CA 2565230

Methods and devices for treating excess mucus accumulation in mammals by administering gaseous inhaled nitric oxide as a mucolytic agent or expectorant are provided. Delivery of gaseous nitric oxide can be made nasally or orally and is preferably substantially coincident with inhalation of the mammal or based on a synchronous parameter of the mammal's respiratory cycle. Varying therapeutic profiles may be used for the delivery of gaseous nitric oxide depending on the severity of the excess mucus accumulation. Parameters for the therapeutic profiles may include flow rate of nitric oxide containing gas, duration of administration of nitric oxide containing gas, number of breaths for which nitric oxide containing gas is to be administered, and concentrations of therapeutic NO delivered to the airways.

La présente invention se rapporte à des méthodes et à des dispositifs permettant de traiter une accumulation excessive de mucus chez des mammifères par administration d'oxyde nitrique inhalé gazeux en tant qu'agent mucolytique ou expectorant. L'administration d'oxyde nitrique gazeux peut se faire par voie nasale ou orale et elle est de préférence sensiblement concomitante à l'inhalation du mammifère ou basée sur un paramètre synchrone du cycle respiratoire dudit mammifère. Divers profils thérapeutiques peuvent être utilisés pour l'administration d'oxyde nitrique gazeux en fonction de la gravité de l'accumulation excessive de mucus. Les paramètres associés aux profils thérapeutiques peuvent inclure le débit du gaz contenant l'oxyde nitrique, la durée d'administration du gaz contenant l'oxyde nitrique, le nombre d'inspirations pendant lesquelles le gaz contenant l'oxyde nitrique doit être administré et les concentrations de NO thérapeutique administrées aux voies aériennes.

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