The use of isolated domains of type iv collagen to modify...

Details The use of isolated domains of type iv collagen to modify... The use of isolated domains of type iv collagen to modify...

A - Human Necessities

61

K

A61K 38/39 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2318432

The instant invention provides methods and kits for inhibiting angiogenesis, tumor growth and metastasis, and endothelial cell interactions with the extracellular matrix, involving contacting the tumor or animal tissue with at least one isolated type IV collagen NC1 .alpha. chain nonomer. In a specific embodiment of the invention, the isolated domain of type IV collagen comprises the NC1 (.alpha.1), (.alpha.2), (.alpha.3), or (.alpha.6) chain monomer, or protein constructs having substantially the same structure as the NC1 (.alpha.1), (.alpha.2), (.alpha.3), or (.alpha.6) chain monomer.

La présente invention concerne des procédés et des trousses servant à inhiber l'angiogenèse, la croissance de tumeurs et les métastases, ainsi que des interactions entre cellules endothéliales et matrice extracellulaire, qui comprennent une étape de mise en contact du tissu tumoral ou animal avec au moins un monomère isolé de la chaîne NC1 .alpha. de collagène du type IV. Dans un mode de réalisation spécifique de l'invention, le domaine isolé de collagène du type IV comprend les monomères de la chaîne NC1 (.alpha.1), (.alpha.2), (.alpha.3) ou (.alpha.6), ou des produits de recombinaison de protéine qui présentent sensiblement la même structure que les monomères de la chaîne NC1 (.alpha.1), (.alpha.2), (.alpha.3) ou (.alpha.6).

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