The use of pde7 inhibitors for the treatment of movement...

Details The use of pde7 inhibitors for the treatment of movement... The use of pde7 inhibitors for the treatment of movement...

A - Human Necessities

61

K

A61K 31/519 (2006.01) A61K 31/198 (2006.01) A61K 31/433 (2006.01) A61K 31/527 (2006.01) A61P 25/14 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2681650

A method of treating a movement abnormality associated with the pathology of a neurological movement disorder, such as Parkinson's disease or Restless Leg(s) Syndrome by administering a therapeutically effective amount of a PDE7 inhibitory agent. An aspect of the invention provides for the administration of a PDE& inhibitory agent in conjunction with a dopamine agonist or precursor, such as levodopa. In another aspect of the invention, the PDE7 inhibitory agent may be selective for PDE7 relative to other molecular targets (i) known to be involved with the pathology of Parkinson's disease or (ii) at which other drug(s) that are therapeutically effective to treat Parkinson's disease act.

La présente invention concerne un procédé de traitement d'une anomalie du mouvement associée à la pathologie d'un trouble du mouvement neurologique, tel que la maladie de Parkinson ou le syndrome des jambes sans repos, par l'administration d'une quantité thérapeutiquement efficace d'un agent inhibiteur PDE7. Un aspect de l'invention concerne l'administration d'un agent inhibiteur PDE& conjointement avec un précurseur ou un agoniste de la dopamine, tel que la lévodopa. Dans un autre aspect de l'invention, l'agent inhibiteur PDE7 peut être sélectif pour PDE7 par rapport à d'autres cibles moléculaires (i) connues pour être impliquées dans la pathologie de la maladie de Parkinson ou (ii) sur lesquelles agissent un ou plusieurs autres médicaments thérapeutiquement efficaces dans le traitement de la maladie de Parkinson.

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