The use of peg-hirudin as an anticoagulant agent in the...

A - Human Necessities – 61 – K

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A61K 47/48 (2006.01) A61K 35/14 (2006.01) A61K 38/58 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2404115

The present invention relates to the use of anticoagulant agents, and in particular of PEG-hirudin, for treating individuals with extracorporeal circulation for prophylaxis of vascular complications after the extracorporeal circulation. It is thus possible in particular to treat individuals with chronic renal insufficiency requiring regular hemodialysis and moreover prevent vascular complications which conventionally result in a high morbidity and mortality rate for dialysis patients treated longer-term.

Utilisation d'anticoagulants, en particulier de PEG-hirudine, pour traiter des sujets soumis à une circulation extracorporelle pour la prophylaxie des complications vasculaires survenant une fois la circulation intracorporelle rétablie. Il est donc possible, en particulier, de traiter des sujets atteints d'insuffisance rénale chronique nécessitant une hémodialyse régulière et de prévenir en outre les complications vasculaires qui entraînent habituellement une morbidité et un taux de mortalité élevés chez les patients dialysés à long terme.

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