The use of plp with peg-rmetase in vivo for enhanced efficacy

Details The use of plp with peg-rmetase in vivo for enhanced efficacy The use of plp with peg-rmetase in vivo for enhanced efficacy

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/51 (2006.01) A61K 47/30 (2006.01) A61P 35/00 (2006.01) A61K 31/765 (2006.01)

Patent

CA 2534995

This invention relates to methods of modifying pyridoxal 5~ phosphate (PLP) dependent enzymes to extend the serum half-life of the enzyme, extend the in vivo period of methionine depletion in a host, and decrease the immunogenicity of the enzyme. A preferred PLP-dependent enzyme to be modified is a methioninase, preferably a recombinant methioninase (rMETase). The invention further relates to compositions comprising a modified PLP-dependent enzyme and methods of using the same.

La présente invention concerne des procédés qui permettent de modifier les enzymes dépendant du pyridoxal 5' phosphate (PLP) afin d'augmenter la demi-vie sérique de l'enzyme, d'augmenter la période in vivo de déplétion en méthionine chez un hôte, et de réduire l'immunogénicité de l'enzyme. Une enzyme dépendante du PLP préférée à modifier est une méthioninase, de préférence une méthioninase recombinée (rMETase). L'invention porte en outre sur des compositions comprenant une enzyme dépendante du PLP modifiée et sur des procédés d'utilisation de cette dernière.

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