A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 51/04 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01)
Patent
CA 2189967
The invention relates to the use of porphyrin-complex or expanded porphyrin-complex compounds for the manufacture of a diagnosticum for the localization of an infarction and of a necrosis, wherein the infarction or necrosis may comprise an infarction of heart, kidney, intestine, lung, and/or brain, and wherein the porphyrin-complex compound may be Gd-MP and/or Mn-TPP. Gd-MP: Bis-Gd- DTPA-(Mesoporphyrin-IX-13, 17-bis[2-oxo-4,7,10,10-tetra-(carboxylatomethyl)-1,4,7,10-tetraazadecyl]-13, 17-diamide}, bis sodium salt of formula (A); Mn-TPP: Manganese-(III)-(Tetrakis-[3]-(carboxylatomethoxy-phenyl)-porphyrin)-acetate, tetra sodium salt of formula (B).
Utilisation de composés à base d'un complexe de porphyrine ou d'un complexe de porphyrine étendue dans la fabrication d'une préparation diagnostique pour la localisation d'un infarctus et d'une nécrose, l'infarctus ou la nécrose pouvant être un infarctus cardiaque, rénal, intestinal, pulmonaire et/ou cérébral, et le composé à base d'un complexe de porphyrine pouvant être le Gd-MP et/ou le Mn-TPP. Gd-MP: sel sodique bis, Bis-Gd-DTPA-{Mésoporphyrin-IX-13,17-bis[2-oxo-4,7,10,10-tétra-(carboxylatométhyl)-1,4,7,10-tétraazadécyl]-13, 17-diamide} de formule (A); Mn-TPP: sel sodique tétra, Manganèse-(III)-{Tétrakis-[3]-(carboxylatométhoxy-phényl)-porphyrin}-acétate de formule (B).
Marchal Guy Jacques Felix
Ni Yicheng
Bereskin & Parr
K.u. Leuven Research & Development
Schering Aktiengesellschaft
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