A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/436 (2006.01) A61K 31/445 (2006.01) A61K 38/13 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2219867
The present invention relates to a use of a proteasome inhibitor to induce apoptosis in proliferating cells. Different functional targets of the proteasome are elucidated, identifying the mode of action of various proteins in cell cycling and apoptosis. The effects of the said proteasome inhibitor on mitochondrial function and nitric oxide production are disclosed along with an assay to identify proteasome inhibitors.
La présente invention porte sur l'utilisation d'un inhibiteur du protéasome pour provoquer l'apoptose chez des cellules prolifératives. Différentes cibles fonctionnelles du protéasome sont mises en évidence, et le mode d'action de diverses protéines dans le cycle cellulaire et l'apoptose est précisé. On décrit les effets dudit inhibiteur du protéasomoe sur la fonction mitonchondriale et la production de monoxyde d'azote ainsi qu'une épreuve d'identification des inhibiteurs du protéasome.
Wang Xin
Wu Jiangping
Centre de Recherche Du Centre Hospitalier de L'universite de Mon
Mccarthy Tetrault Llp
Universite de Montreal
Wang Xin
Wu Jiangping
LandOfFree
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