A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/00 (2006.01) A61K 31/436 (2006.01) A61K 31/445 (2006.01) A61K 38/13 (2006.01)
Patent
CA 2276013
The present invention relates to compositions comprising proteasome inhibitors, such as lactocystin and analogues thereof. These compositions are used for the following purposes: (1) to disrupt mitochondrial function (useful against cancer, inflammation, adverse immune reaction and hyperthyroidism), (2) to disrupt nitric oxide synthesis (useful against inflammation and septic shock), and (3) to reverse ongoing adverse immune reactions, such as autoimmune diseases and graft rejection. In the later case, the compositions are administered once the patient's T cells are mostly activated. Proteasome inhibitors can also be combined to immuno-suppressive drugs like rapamycin, cyclosporin A and FK506. Finally, a method for screening a compound having a proteasome inhibition activity is also disclosed and claimed.
Wang Xin
Wu Jiangping
Centre de Recherche Du Centre Hospitalier de L'universite de Mon
Mccarthy Tetrault Llp
Universite de Montreal
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