The use of quaternary pyridinium salts as vasoprotective agents

Details The use of quaternary pyridinium salts as vasoprotective agents The use of quaternary pyridinium salts as vasoprotective agents

A - Human Necessities

61

K

A61K 31/4425 (2006.01) A61P 1/04 (2006.01) A61P 1/16 (2006.01) A61P 3/04 (2006.01) A61P 3/10 (2006.01) A61P 9/00 (2006.01) A61P 9/10 (2006.01) A61P 9/12 (2006.01) A61P 11/00 (2006.01) A61P 15/10 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 41/00 (2006.01)

Patent

CA 2547234

The invention relates to the use of quaternary pyridinium salts of for~mula (1), wherein wherein R is NH2, CH3, or N(H)CH2OH group, and X is pharmaceutically acceptable counterion, for the preparation of vasopro~tective agent for the treatment or prevention of conditions or diseases associated with dysfunction of vascular endothelium, oxidative stress, and/or insufficient production of endothelial prostacyclin PGI2, in par~ticular but not exclusively if the above coincides with hypercholes terolemia, hypertriglyceridemia or low HDL level.

L'invention concerne l'utilisation de sels de pyridinium quaternaire de formule (I), dans laquelle R est NH¿2?, CH¿3?, ou un groupe N(H)CH¿2?OH, et X est un contre-ion pharmaceutiquement acceptable, pour la préparation d'un agent vasoprotecteur destiné au traitement ou à la prévention de pathologies ou d'affections associées à un dysfonctionnement de l'endothélium vasculaire, au stress oxydatif, et/ou à la production insuffisante de prostacycline endothéliale PGI¿2?, notamment mais pas exclusivement si les troubles précités coïncident avec une hypercholestérolémie, une hypertriglycéridémie ou un faible taux de lipoprotéines de haute densité.

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