A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/605 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2696874
The present invention relates to an effective fraction of alkaloids and the effective fraction is prepared from mulberry twig and its active ingredients are a composition of alkaloids. Determined by HPLC, the percentage of the total alkaloids are 50% or more by weight in the effective fraction and the percentage of the compound 1-deoxynojirimycin is 30% or more by weight in the total alkaloids. The effective fraction of the invention is prepared as the following steps: the mulberry twig is extracted by solvents, and the extract is precipitated by alcohol precipitation or flocculation to remove the impurities, and then concentrated, purified by resin chromatography. The present invention also relates to a pharmaceutical composition containing the said effective fraction of alkaloids and to the use of the effective fraction of alkaloids according to claim 1-4 in preparing hypoglycemic agents.
La présente invention concerne une section efficace fabriquée à partir de Ramulus Mori sous forme de drogue, le total des alcaloïdes représentant 50 % de plus en poids par rapport à la section efficace, et le composé 1-déoxynojirimycine représentant 30 % de plus en poids par rapport au total des alcaloïdes. La présente invention concerne également le procédé de préparation de ladite section efficace et de la composition pharmaceutique contenant la section efficace, ainsi que l'utilisation de la section efficace dans la préparation d'un agent hypoglycémiant.
Chen Yueteng
Chen Zhen
Liu Quan
Liu Yuling
Shen Zhufang
Benoit & Cote Associes Inc.
Institute Of Mataria Medica Chinese Academy Of Medical Sciences
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