The use of yop proteins or rho gtpase inhibitors as...

A - Human Necessities – 61 – K

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A61K 38/16 (2006.01) A61P 1/00 (2006.01) A61P 25/28 (2006.01) C07K 14/24 (2006.01)

Patent

CA 2513584

The present invention relates to the use of Yops (Yersinia outer membrane proteins) as caspase inhibitor. More specifically, it relates to the use of YopE and YopT as inhibitor of the caspase-1 activity. Said inhibitor can be used to treat caspase-1 related pathologies such as inflammatory diseases, or to inhibit caspase-1 related cell death.

L'invention concerne l'utilisation de Yops (protéines de membrane extérieure de Yersinia) en tant qu'inhibiteur de caspase. Elle concerne, plus particulièrement, l'utilisation de YopE et YopT en tant qu'inhibiteur de l'activité de caspase-1. Cet inhibiteur peut être utilisé afin de traiter des pathologies associées à caspase-1 telles que des maladies inflammatoires ou d'inhiber l'apoptose associée à caspase-1.

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