Theophylline immunogens, antibodies, labeled conjugates, and...

Details Theophylline immunogens, antibodies, labeled conjugates, and... Theophylline immunogens, antibodies, labeled conjugates, and...

C - Chemistry, Metallurgy

07

H

167/139, 260/228

C07H 15/26 (2006.01) C07D 473/08 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/549 (2006.01) G01N 33/94 (2006.01)

Patent

CA 1210757

ABSTRACT OF THE DISCLOSURE Theophylline immunogens, antibodies prepared there- from, labeled theophylline conjugates, synthetic inter- mediates, and the use of such antibodies and labeled conjugates in immunoassays for determining theophylline. The immunogens comprise theophylline coupled at its 9-position to an immunogenic carrier material. Likewise, the labeled conjugates and synthetic intermediates are 9-position derivatives of theophylline or synthetic precursors thereof. The antibody and labeled reagents are particularly useful in homogeneous nonradioisotopic immunoassays for measuring theophylline in biological fluids such as serum.

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