Theramutein modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 237/02 (2006.01)

Patent

CA 2567813

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

L'invention concerne des agents inhibiteurs ou activateurs de formes de variants de protéines endogènes ainsi que de nouveaux procédés permettant d'identifier ces variants. Elle concerne des inhibiteurs et activateurs de variants de protéines endogènes particulièrement intéressants qui sont codés par des gènes ayant muté. Ces variants se produisent souvent ou sont au moins d'abord identifiés comme se produisant à la suite d'une exposition à un agent chimique connu comme étant un inhibiteur ou un activateur de la protéine endogène non mutée correspondante.

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