Theramutein modulators

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/48 (2006.01) A61K 31/44 (2006.01) A61K 31/505 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 213/81 (2006.01) C07D 239/84 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2620878

This invention relates to agents that are inhibitors or activators of variant forms of endogenous proteins and novel methods of identifying such variants. Of particular interest are inhibitors and activators of endogenous protein variants, encoded by genes which have mutated, which variants often arise or are at least first identified as having arisen following exposure to a chemical agent which is known to be an inhibitor or activator of the corresponding unmutated endogenous protein.

Cette invention concerne des agents qui sont des inhibiteurs ou des activateurs de formes de variants de protéines endogènes et concerne également de nouvelles méthodes d'identification de tels variants. Des inhibiteurs et des activateurs de variants de protéines endogènes, codés par des gènes ayant muté, présentent un intérêt particulier, lesquels variants apparaissent souvent ou sont au moins d'abord identifiés comme étant apparus à la suite d'une exposition à un agent chimique connu pour être un inhibiteur ou un activateur de la protéine endogène non mutée correspondante.

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