C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/50 (2006.01) A61K 38/48 (2006.01) C07K 5/06 (2006.01) C07K 5/065 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2056402
This invention relates to chymopapain, improved pharmaceutical compositions containing chymopapain and to methods of treating damaged, herniated or otherwise abnormal intervertebral mammalian spinal discs which comprise injecting into said discs a solution of the improved composition. The invention further relates to processes for preparing the chymopapain of the invention, to inhibitory peptides and affinity chromatography matrices of use in such processes, and to monospecific antibody preparations raised against chymopapain.
Chymopapaïne, composé pharmaceutique amélioré contenant de la chymopapaïne et procédés pour soigner chez les mammifères des disques intervertébraux endommagés, herniés ou frappés d'une autre anomalie, consistant à y injecter une solution dudit composé. L'invention porte également sur des procédés pour préparer ladite chymopapaïne, sur des peptides d'inhibition et sur des matrices de chromatographie par affinité servant à la mise en oeuvre de ces procédés; elle porte enfin sur des préparations d'anticorps monospécifiques élevés contre la chymopapaïne.
Barrett Alan J.
Buttle David J.
Rich Daniel H.
Mccarthy Tetrault Llp
The Boots Company Plc
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