Therapeutic agent composition and method of use

Details Therapeutic agent composition and method of use Therapeutic agent composition and method of use

A - Human Necessities

61

K

A61K 31/4985 (2006.01) A61K 31/198 (2006.01) A61K 38/00 (2006.01) A61K 38/12 (2006.01) A61K 38/18 (2006.01) A61K 38/19 (2006.01) A61K 38/27 (2006.01) A61K 38/30 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2466701

The invention also relates to the use of cyclic Prolyl Glycine ("cyclic PG" or "cPG") and analoges and mimetics thereof, as neuroprotective agents for the tratement and or prevention of neurological disorders including but not limited ot cerebral ischemia or cerebral infaction resulting from a range of phenomena, such as thromboembolic or hemorrhagic stroke, cerebral basospasms, hypoglycemia, cardic arrest, status epilepticus, perinatal asphyxia, anoxia sah as from drowning, pulmonary surger, and cerebral trauma, as well as to the treatment and prevention of chronic neurodenenerative disorders such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, and as anticonvulsants.

La présente invention se rapporte à l'utilisation de la prolyl-glycine cyclique (<= PG cyclique >= ou <= CPG >=) et de ses analogues et mimétiques en tant qu'agents neuroprotecteurs pour le traitement et/ou la prévention de troubles neurologiques comprenant, non exclusivement, l'ischémie cérébrale ou l'infarctus cérébral résultant d'une diversité de phénomènes du type attaque d'apoplexie thromboembolique ou attaque d'apoplexie hémorragique, basospasmes cérébraux, hypoglycémie, arrêt cardiaque, status epilepticus, asphyxie périnatale, anoxie telle que l'anoxie par noyade, chirurgie pulmonaire et traumatisme cérébral, lesdits agents pouvant également servir au traitement et à la prévention de troubles neurodégénératifs chroniques tels que la maladie d'Alzheimer, la maladie de Parkinson et la maladie de Huntington, ainsi qu'en tant qu'anti-convulsifs.

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