Therapeutic agent comprising a b-subunit of a protein toxin

Details Therapeutic agent comprising a b-subunit of a protein toxin Therapeutic agent comprising a b-subunit of a protein toxin

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 39/295 (2006.01) A61P 31/12 (2006.01) A61P 35/00 (2006.01) C07K 14/05 (2006.01) C07K 14/245 (2006.01) C07K 14/28 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2434915

A B-subunit of a protein toxin selected from the B-subunit ofE. coli heat- labile enterotoxin (EtxB) and the B-subunit of Vibrio cholerae toxin (CtxB) has a therapeutic effect against cell surface-expressed viral antigens and tumour antigens. In particular, the protein toxin may be used to treat an animal body, including human, suffering from a disease or condition associated with Epstein Barr Virus or suffering from neoplasia. The therapeutic agent may, additionally, comprise a cell surface-expressed antigen, for instance an Epstein Barr Virus latent membrane protein.

Une sous-unité "B" d'une toxine protéique sélectionnée dans la sous-unité B d'entéroxine de E. coli instable à la chaleur (EtxB) et la sous-unité B de la toxine de Vibrio cholerae (CtxB) a un effet thérapeutique contre les antigènes viraux exprimés à la surface des cellules et les antigènes tumoraux. La toxine de protéine peut s'utiliser pour traiter un corps animal, y compris humain, souffrant d'une maladie ou d'un état associé au virus d'Epstein Barr ou souffrant de néoplasie. L'agent thérapeutique peut en outre comprendre un antigène viral exprimé à la surface des cellules tel que la protéine de membrane latente du virus d'Epstein Barr.

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